Investigations
What is an Investigation?Filters
We face a crisis in reproducibility, where it is impossible to believe most of the computational results shown in conferences and papers. Recent replication efforts and theoretical considerations indicate that most published research findings in biomedical research are wrong. This is especially problematic for the translation of computational models into the clinics. Modelling standards, software, and community initiatives are fundamental for reproducibility in systems biology and systems medicine. ...
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Submitter: Matthias König
Studies: PKDB Caffeine Study
Assays: Digitized pharmacokinetics data (Akinyinka2000), Digitized pharmacokinetics data (Amchin1999), Digitized pharmacokinetics data (Blanchard1983a), Digitized pharmacokinetics data (Haller2002), Digitized pharmacokinetics data (Healy1991), Digitized pharmacokinetics data (Hetzler1990), Digitized pharmacokinetics data (Jeppesen1996), Digitized pharmacokinetics data (Kakuda2014), Digitized pharmacokinetics data (Kaplan1997), Digitized pharmacokinetics data (Magnusson2008), Digitized pharmacokinetics data (Oh2012), Digitized pharmacokinetics data (Perera2011), Digitized pharmacokinetics data (Spigset1999a), Digitized pharmacokinetics data (Tanaka2014)
Introduction: The field of pharmacokinetics describe the kinetics of substances administered to the body, consisting of absorption, distribution, metabolization and elimination (ADME) of the substance. An important use case is the testing of liver function via test substances like caffeine, methacetin or galactose in dynamical liver function tests. Understanding the kinetics of test substances and drugs is crucial to evaluate therapeutic outcome and diagnostic value.
Results: Physiologically based ...
Submitter: Matthias König
Studies: PK-DB: PharmacoKinetics DataBase for Individualized and Stratified Compu...
Assays: No Assays
Collection of Presentations and Posters from Dresden LiSyM Jamboree (LiFuDi & MM-PLF)
Pillar IV Jamboree • (10 min) Introduction to Pillar IV (Hergo Holzhütter) • (20 min) Precise Measurement of Hepatic Elasticity for Fibrosis Detection (Christian Hudert) • (20 min) Tissue Scale Metabolic Modelling (Sascha Bulik) • (10 min) Multi-scale models for liver function tests (Matthias König) • (20 min) Improving the diagnostic precision of the 13C-methacetin dynamic liver function test (LiMAx) (Tilo ...
