Tools: Cytometry and fluorescent microscopy, rtPCR, Mouse surgery, Cell and tissue culture, RNA analysis, confocal microscopy, Milliplex analysis, Isolation and cultivation of mouse hepatocyte, Immunohistochemistry, qPCR, Preparation and differentiation of bone marrow derived macrophages, Mouse experiments in vivo (LPS PHx MCMV), Molecular Biology, Laser scan microscopy
I received my diploma in biology in 2001 from the Heinrich-Heine-University in Duesseldorf and the Dr. rer. nat. (Ph.D.) degree in 2006 from the University of Hohenheim in Germany. The practical part of my Ph.D. thesis had been realized at the clinic for gastroenterology, hepatology and infectiology at the university hospital in Duesseldorf. After my Ph.D. I focussed my studies on LPS-, PHx- and CMV-induced MAP-kinase-regulated intra- or intercellular signal transduction and immune cell recruitment
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), Early Metabolic Injury (LiSyM-EMI - Pillar I), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network
Institutions: HITS gGmbHorcid.org/0000-0002-8683-7084
Data management and standardization expert for systems biology and systems medicine, responsible for the data management user requirements and user contacts within the German LiSyM network (Liver Systems Medicine: http://lisym.org/) and associated to the FAIRDOM team.
Involved in different standardization initiatives and committees, i.e. COMBINE (http://co.mbine.org), ISO/TC 276 Biotechnology (https://www.iso.org/committee/4514241.html), European COST action CHARME (http://www.cost-charme.eu) and