Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD).

Abstract:

The prevalence of nonalcoholic fatty liver disease (NAFLD), recently also re-defined as metabolic dysfunction associated fatty liver disease (MAFLD), is rapidly increasing, affecting ~25% of the world population. MALFD/NAFLD represents a spectrum of liver pathologies including the more benign hepatic steatosis and the more advanced non-alcoholic steatohepatitis (NASH). NASH is associated with enhanced risk for liver fibrosis and progression to cirrhosis and hepatocellular carcinoma. Hepatic stellate cells (HSC) activation underlies NASH-related fibrosis. Here, we discuss the profibrogenic pathways, which lead to HSC activation and fibrogenesis, with a particular focus on the intercellular hepatocyte-HSC and macrophage-HSC crosstalk.

SEEK ID: https://seek.lisym.org/publications/340

PubMed ID: 35805998

Projects: DEEP-HCC network

Publication type: Journal

Journal: Int J Mol Sci

Citation: Int J Mol Sci. 2022 Jun 23;23(13). pii: ijms23136996. doi: 10.3390/ijms23136996.

Date Published: 23rd Jun 2022

Registered Mode: by PubMed ID

Authors: P. Subramanian, J. Hampe, F. Tacke, T. Chavakis

Help
help Submitter
Activity

Views: 114

Created: 17th Oct 2022 at 13:34

help Tags

This item has not yet been tagged.

help Attributions

None

Related items

Powered by
(v.1.11.1)
Copyright © 2008 - 2021 The University of Manchester and HITS gGmbH

LiSyM Seek uses essential cookies to keep your session open and to save if you accept this banner.

By continuing to use this site you agree to the use of cookies