Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD).


The prevalence of nonalcoholic fatty liver disease (NAFLD), recently also re-defined as metabolic dysfunction associated fatty liver disease (MAFLD), is rapidly increasing, affecting ~25% of the world population. MALFD/NAFLD represents a spectrum of liver pathologies including the more benign hepatic steatosis and the more advanced non-alcoholic steatohepatitis (NASH). NASH is associated with enhanced risk for liver fibrosis and progression to cirrhosis and hepatocellular carcinoma. Hepatic stellate cells (HSC) activation underlies NASH-related fibrosis. Here, we discuss the profibrogenic pathways, which lead to HSC activation and fibrogenesis, with a particular focus on the intercellular hepatocyte-HSC and macrophage-HSC crosstalk.


PubMed ID: 35805998

Projects: DEEP-HCC network

Publication type: Journal

Journal: Int J Mol Sci

Citation: Int J Mol Sci. 2022 Jun 23;23(13). pii: ijms23136996. doi: 10.3390/ijms23136996.

Date Published: 23rd Jun 2022

Registered Mode: by PubMed ID

Authors: P. Subramanian, J. Hampe, F. Tacke, T. Chavakis

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Created: 17th Oct 2022 at 13:34

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