TiSim - A Workbench and Framework for Biophysical Agent-Based Multi-Scale Multi-Cellular Models. Version 1
Computational models complement experimental methods in the analysis of tissue organization processes, and play an increasingly important role in systems biology and systems medicine. Creating and parameterizing mathematical models for the simulation of biological tissue dynamics at multiple scales is still a complex and resource-consuming task, which necessitates skills in diverse scientific disciplines. The software TiSim was conceived to facilitate programming, integration and deployment of computational/mathematical tissue models by providing a framework which readily adapts the models to a graphical user interface, enabling interested third parties to interact with the implemented models, and making virtual experiments possible in a workbench-like fashion.
SEEK ID: https://seek.lisym.org/presentations/129?version=1
Filename:
2018_SBMC_TJ_pptx.pdf
Format: PDF document
Size: 10.9 MB
Export PNG
Creators and SubmitterCreators
Additional credit
Andreas Buttenschön, Noémie Boissier, Géraldine Cellière, Paul Van Liedekerke, Johannes Neitsch
Submitter
Views: 2645 Downloads: 697
Created: 17th Jul 2018 at 09:04
TagsThis item has not yet been tagged.
AttributionsNone
Version History
Version 1 (earliest) Created 17th Jul 2018 at 09:04 by Tim Johann
No revision comments
Related items
Projects: LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM network, LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Scientific Leadership Team (LiSyM-LT), LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, C-TIP-HCC network
Institutions: INRIA (French National Institute for Research in Computer Science and Control), Leibniz-Institut für Arbeitsforschung (IfADo)
Projects: LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM network, LiSyM-Krebs Partnering, Forschungsnetzwerk LiSyM-Krebs, SMART-NAFLD, C-TIP-HCC network
Institutions: Universität Leipzig - Institute for Computer Science (Bioinformatics), Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie
https://orcid.org/0000-0001-5792-1562
Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
In one in five people with NAFLD, the functioning liver cells, the hepatocytes, are replaced by connective tissue. Eventually this fibrosis becomes irreversible. In this state the liver is like a ‘scar that never heals’. Through it, the liver loses many of its vital functions. LiSyM-Pillar II wants to know more about which factors promote fibrosis and the conditions under which fibrosis becomes irreversible How can fibrosis be diagnosed as early as possible? Researchers in the pillar are also ...
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research
Start date: 1st Jan 2016
