SEEK ID: https://seek.lisym.org/people/98
Location: Germany
ORCID: Not specified
Joined: 24th Apr 2018
Expertise: Not specified
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Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
This comprises the whole LiSyM network
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org
Start date: 1st Jan 2016
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
One of the tasks of the healthy liver is to store fat. Yet, at some stage, too much fat makes the liver sick. One critical time point occurs when a healthy fatty liver becomes inflamed and progresses to steatohepatitis, or NASH. LiSyM-Pillar I will identify what events lead to this transition. Does it occur in all parts of the liver? Which molecules indicate that it is taking place? Can the degeneration be stopped or undone - and if so, how?
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research/zones-of-the-liver
Start date: 1st Jan 2016
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus, Homo sapiens
Abstract (Expand)
Authors: J. Karschau, A. Scholich, J. Wise, H. Morales-Navarrete, Y. Kalaidzidis, M. Zerial, B. M. Friedrich
Date Published: 1st Jul 2020
Publication Type: Journal
PubMed ID: 32598356
Citation: PLoS Comput Biol. 2020 Jun 29;16(6):e1007965. doi: 10.1371/journal.pcbi.1007965. eCollection 2020 Jun.
Abstract (Expand)
Authors: K. Meyer, H. Morales-Navarrete, S. Seifert, M. Wilsch-Braeuninger, U. Dahmen, E. M. Tanaka, L. Brusch, Y. Kalaidzidis, M. Zerial
Date Published: 25th Feb 2020
Publication Type: Journal
PubMed ID: 32090478
Citation: Mol Syst Biol. 2020 Feb;16(2):e8985. doi: 10.15252/msb.20198985.
Abstract (Expand)
Authors: F. Segovia-Miranda, H. Morales-Navarrete, M. Kucken, V. Moser, S. Seifert, U. Repnik, F. Rost, M. Brosch, A. Hendricks, S. Hinz, C. Rocken, D. Lutjohann, Y. Kalaidzidis, C. Schafmayer, L. Brusch, J. Hampe, M. Zerial
Date Published: 2nd Dec 2019
Publication Type: Not specified
PubMed ID: 31792455
Citation: Nat Med. 2019 Dec 2. pii: 10.1038/s41591-019-0660-7. doi: 10.1038/s41591-019-0660-7.
Abstract (Expand)
Authors: H. Morales-Navarrete, H. Nonaka, A. Scholich, F. Segovia-Miranda, W. de Back, K. Meyer, R. L. Bogorad, V. Koteliansky, L. Brusch, Y. Kalaidzidis, F. Julicher, B. M. Friedrich, M. Zerial
Date Published: 17th Jun 2019
Publication Type: Not specified
PubMed ID: 31204997
Citation: Elife. 2019 Jun 17;8. pii: 44860. doi: 10.7554/eLife.44860.
Abstract (Expand)
Authors: C. Franke, U. Repnik, S. Segeletz, N. Brouilly, Y. Kalaidzidis, J. M. Verbavatz, M. Zerial
Date Published: 17th Jun 2019
Publication Type: Not specified
PubMed ID: 31206952
Citation: Traffic. 2019 Jun 17. doi: 10.1111/tra.12671.