SEEK ID: https://seek.lisym.org/people/63
Location: Germany
ORCID: https://orcid.org/0000-0002-9984-075X
Joined: 21st Jul 2017
Expertise: Not specified
Tools: Not specified
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Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
One of the tasks of the healthy liver is to store fat. Yet, at some stage, too much fat makes the liver sick. One critical time point occurs when a healthy fatty liver becomes inflamed and progresses to steatohepatitis, or NASH. LiSyM-Pillar I will identify what events lead to this transition. Does it occur in all parts of the liver? Which molecules indicate that it is taking place? Can the degeneration be stopped or undone - and if so, how?
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research/zones-of-the-liver
Start date: 1st Jan 2016
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus, Homo sapiens
This comprises the whole LiSyM network
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org
Start date: 1st Jan 2016
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
Abstract (Expand)
Authors: Roman Tremmel, Anne T. Nies, Barbara A. C. van Eijck, Niklas Handin, Mathias Haag, Stefan Winter, Florian A. Büttner, Charlotte Kölz, Franziska Klein, Pascale Mazzola, Ute Hofmann, Kathrin Klein, Per Hoffmann, Markus M. Nöthen, Fabienne Z. Gaugaz, Per Artursson, Matthias Schwab, Elke Schaeffeler
Date Published: 1st Jul 2022
Publication Type: Journal
DOI: 10.3390/ijms23137468
Citation: IJMS 23(13):7468
Abstract (Expand)
Authors: Y. Wang, B. Moussian, E. Schaeffeler, M. Schwab, A. T. Nies
Date Published: 12th Jun 2018
Publication Type: Not specified
PubMed ID: 29890226
Citation: Drug Discov Today. 2018 Oct;23(10):1746-1760. doi: 10.1016/j.drudis.2018.06.002. Epub 2018 Jun 8.
Abstract (Expand)
Authors: P. Fisel, E. Schaeffeler, M. Schwab
Date Published: 17th Apr 2018
Publication Type: Not specified
PubMed ID: 29660777
Citation: Clin Transl Sci. 2018 Jul;11(4):352-364. doi: 10.1111/cts.12551. Epub 2018 Apr 16.
Abstract (Expand)
Authors: Ryoichi Fujiwara, Mathias Haag, Elke Schaeffeler, Anne T. Nies, Ulrich M. Zanger, Matthias Schwab
Date Published: 1st Apr 2018
Publication Type: Not specified
DOI: 10.1002/hep.29599
Citation: Hepatology 67(4) : 1609
Abstract (Expand)
Authors: J. Johanning, P. Kroner, M. Thomas, U. M. Zanger, A. Norenberg, M. Eichelbaum, M. Schwab, H. Brauch, W. Schroth, T. E. Murdter
Date Published: 28th Dec 2017
Publication Type: Not specified
PubMed ID: 29285606
Citation: Arch Toxicol. 2017 Dec 28. pii: 10.1007/s00204-017-2147-y. doi: 10.1007/s00204-017-2147-y.