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- Hergo Holzhütter
SEEK ID: https://seek.lisym.org/people/54
Location:
Germany
Expertise: Not specified
Tools: Not specified
ORCID: Not specified
LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi) (Charité - Universitätsmedizin Berlin, Institute of Biochemistry, Computational Systems Biochemistry Group)
Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM) (Charité - Universitätsmedizin Berlin, Institute of Biochemistry, Computational Systems Biochemistry Group) ; LiSyM network (Charité - Universitätsmedizin Berlin, Institute of Biochemistry, Computational Systems Biochemistry Group) ; LiSyM Scientific Leadership Team (LiSyM-LT) (Charité - Universitätsmedizin Berlin, Institute of Biochemistry, Computational Systems Biochemistry Group) ; LiSyM-Krebs Partnering (Charité - Universitätsmedizin Berlin, Institute of Biochemistry, Computational Systems Biochemistry Group)
Related items
This generic project is intended to be a forum for all LiSyM partner and external stakeholders interested in participating in the BMBF initiative LiSyM-Krebs.
Programme: LiSyM-Krebs
Public web page: https://www.ptj.de/projektfoerderung/gesundheitsforschung/lisym-krebs
Organisms: Not specified
Disorders of the liver show up through changes in blood tests. These blood tests indicate markers for events taking place in the liver. Usually studies of liver tissue cannot be performed: as liver samples would need to be obtained through a liver biopsy, and this procedure is not without risk, therefore these samples are usually unavailable. Complex metabolism models based on existing and new scientific data can simulate changes in the liver caused by disease. They often reveal unknown relationships
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Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research/the-liver-is-very-patient
Start date: 1st Jan 2016
Organisms: Homo sapiens
Day-to-day science within the LiSyM is overseen and directed by the the LiSyM Scientific Leadership Team. This coordination team comprises the pillar coordinators and additional LiSyM members, and ensures smooth interaction between multi-skilled groups, often working in different institutions and across significant distances within Germany.
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/who-we-are
Organisms: Not specified
Dr. Nachiket Vartak (TU University, Dortmund) investigates the role of a particular protein - the GTPase Rab18 - in initiating NAFLD. He tries to influence Rab18 pharmacologically so that NAFLD is not initiated. Vartak also analyzes how bile acids leave the liver. He hopes to find ways to improve the flow of bile in a liver with dysfunctional bile flow.
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/junior-group/the-protein-rab18
Start date: 1st Jan 2016
Organisms: Homo sapiens, Mus musculus
This comprises the whole LiSyM network
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org
Start date: 1st Jan 2016
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
Abstract (Expand)
Authors: C. A. Hudert, H. Tzschatzsch, B. Rudolph, C. Loddenkemper, H. G. Holzhutter, L. Kalveram, S. Wiegand, J. Braun, I. Sack, J. Guo
Date Published: 17th Jan 2021
Publication Type: Journal
PubMed ID: 33472102
Citation: Acta Biomater. 2021 Jan 17. pii: S1742-7061(21)00046-5. doi: 10.1016/j.actbio.2021.01.019.
Abstract (Expand)
Authors: L. Kalveram, W. H. Schunck, M. Rothe, B. Rudolph, C. Loddenkemper, H. G. Holzhutter, S. Henning, P. Bufler, M. Schulz, D. Meierhofer, I. W. Zhang, K. H. Weylandt, S. Wiegand, C. A. Hudert
Date Published: 4th Jan 2021
Publication Type: Journal
PubMed ID: 33388475
Citation: Prostaglandins Leukot Essent Fatty Acids. 2021 Jan;164:102229. doi: 10.1016/j.plefa.2020.102229. Epub 2020 Dec 17.
Abstract (Expand)
Authors: K. Garczynska, H. Tzschatzsch, A. A. Kuhl, A. S. Morr, L. Lilaj, A. Hackel, E. Schellenberger, N. Berndt, H. G. Holzhutter, J. Braun, I. Sack, J. Guo
Date Published: 17th Dec 2020
Publication Type: Journal
PubMed ID: 33329058
Citation: Front Physiol. 2020 Nov 23;11:605205. doi: 10.3389/fphys.2020.605205. eCollection 2020.
Abstract (Expand)
Authors: N. Berndt, J. Eckstein, N. Heucke, T. Wuensch, R. Gajowski, M. Stockmann, D. Meierhofer, H. G. Holzhutter
Date Published: 8th Oct 2020
Publication Type: Journal
PubMed ID: 33030799
Citation: FEBS J. 2020 Oct 8. doi: 10.1111/febs.15587.
Abstract (Expand)
Authors: N. Berndt, E. Kolbe, R. Gajowski, J. Eckstein, F. Ott, D. Meierhofer, H. G. Holzhutter, M. Matz-Soja
Date Published: 14th Apr 2020
Publication Type: Not specified
PubMed ID: 32286709
Citation: Hepatology. 2020 Apr 14. doi: 10.1002/hep.31274.