SEEK ID: https://seek.lisym.org/people/43
Location: Germany
ORCID: https://orcid.org/0000-0003-1244-9369
Joined: 22nd May 2017
Expertise: Not specified
Tools: Not specified
Related items
Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
Disorders of the liver show up through changes in blood tests. These blood tests indicate markers for events taking place in the liver. Usually studies of liver tissue cannot be performed: as liver samples would need to be obtained through a liver biopsy, and this procedure is not without risk, therefore these samples are usually unavailable. Complex metabolism models based on existing and new scientific data can simulate changes in the liver caused by disease. They often reveal unknown relationships ...
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research/the-liver-is-very-patient
Start date: 1st Jan 2016
Organisms: Homo sapiens
This comprises the whole LiSyM network
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org
Start date: 1st Jan 2016
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
The data file contains basal information About the enroled study subjects. Further Details are provided upon request to tilo.wuensch@charite.de
Creators: None
Submitter: Tilo Wuensch
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Abstract (Expand)
Authors: N. Berndt, J. Eckstein, Niklas Heucke, T. Wuensch, R. Gajowski, M. Stockmann, D. Meierhofer, H. G. Holzhutter
Date Published: 8th Oct 2020
Publication Type: Journal
PubMed ID: 33030799
Citation: FEBS J. 2020 Oct 8. doi: 10.1111/febs.15587.
Abstract (Expand)
Authors: H. G. Holzhutter, T. Wuensch, R. Gajowski, N. Berndt, S. Bulik, D. Meierhofer, M. Stockmann
Date Published: 6th Feb 2020
Publication Type: Not specified
PubMed ID: 32020249
Citation: Arch Toxicol. 2020 Feb;94(2):401-415. doi: 10.1007/s00204-020-02654-0. Epub 2020 Feb 4.
Abstract (Expand)
Authors: T. Wuensch, J. Wizenty, J. Quint, W. Spitz, M. Bosma, O. Becker, A. Adler, W. Veltzke-Schlieker, M. Stockmann, S. Weiss, M. Biebl, J. Pratschke, F. Aigner
Date Published: 17th May 2019
Publication Type: Not specified
PubMed ID: 31093274
Citation: Gastroenterol Res Pract. 2019 Apr 9;2019:3784172. doi: 10.1155/2019/3784172. eCollection 2019.
Abstract (Expand)
Authors: T. Wuensch, J. Quint, V. Mueller, A. Mueller, J. Wizenty, M. Kaffarnik, B. Kern, M. Stockmann, M. Biebl, J. Pratschke, F. Aigner
Date Published: 25th Mar 2019
Publication Type: Not specified
PubMed ID: 30904213
Citation: Clin Nutr ESPEN. 2019 Apr;30:131-137. doi: 10.1016/j.clnesp.2019.01.004. Epub 2019 Jan 31.
Abstract (Expand)
Authors: T. Wuensch, Niklas Heucke, J. Wizenty, J. Quint, B. Sinn, R. Arsenic, M. Jara, M. Kaffarnik, J. Pratschke, M. Stockmann
Date Published: 14th Mar 2019
Publication Type: Not specified
PubMed ID: 30869529
Citation: Am J Physiol Gastrointest Liver Physiol. 2019 Mar 14. doi: 10.1152/ajpgi.00335.2018.
Abstract (Expand)
Authors: Niklas Heucke, T. Wuensch, J. Mohr, M. Kaffarnik, R. Arsenic, B. Sinn, T. Muller, J. Pratschke, M. Stockmann, I. Sack, H. Tzschatzsch
Date Published: 13th Feb 2019
Publication Type: Not specified
PubMed ID: 30756433
Citation: J Gastroenterol Hepatol. 2019 Feb 13. doi: 10.1111/jgh.14629.
Abstract (Expand)
Authors: N. Berndt, S. Bulik, I. Wallach, T. Wunsch, M. Konig, M. Stockmann, D. Meierhofer, H. G. Holzhutter
Date Published: 21st Jun 2018
Publication Type: Not specified
PubMed ID: 29921957
Citation: Nat Commun. 2018 Jun 19;9(1):2386. doi: 10.1038/s41467-018-04720-9.
Improving liver funcion diagnostics by developing computitional models based on patients' data (liver function, liver stiffness, clinical data, proteomics, specific enzyme activities) and translation of modeling results in clinical practice
Creator: Tilo Wuensch
Submitter: Tilo Wuensch
Pillar IV Jamboree • (10 min) Introduction to Pillar IV (Hergo Holzhütter) • (20 min) Precise Measurement of Hepatic Elasticity for Fibrosis Detection (Christian Hudert) • (20 min) Tissue Scale Metabolic Modelling (Sascha Bulik) • (10 min) Multi-scale models for liver function tests (Matthias König) • (20 min) Improving the diagnostic precision of the 13C-methacetin dynamic liver function test (LiMAx) (Tilo Wünsch) • (20 min) Mathematical Modelling of Improved Liver Function Breath Test (Hergo ...
Creator: Tilo Wuensch
Submitter: Matthias König