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17 Presentations visible to you, out of a total of 19

PK-DB: PharmacoKinetics DataBase for Individualized and Stratified Computational Modeling Jan Grzegorzewski, Janosch Brandhorst, Dimitra Eleftheriadou, Kathleen Green, Matthias König bioRxiv 760884; doi: https://doi.org/10.1101/760884

Creators: Matthias König, Jan Grzegorzewski

Submitter: Matthias König

We face a reproducibility crisis and computational science, with most published models neither being accessible nor reproducible. The Systems Biology Markup Language (SBML) is the de facto standard format for encoding pathway based models, which provides a means for exchanging process based models between researchers and tools. The talk gives an overview of SBML and SBML-based tools.

Creator: Matthias König

Submitter: Matthias König

Assessment of liver function is a key task in hepatology but accurate quantification of hepatic function has remained a clinical challenge. Dynamic liver function tests are a promising tool for the non-invasive evaluation of liver function in vivo. Quantitative dynamical liver function tests evaluate the function of the liver via the clearance of a given test substance, thereby providing in vivo information on the metabolic capacity of the liver. Here, we present recent results in establishing ...

Creator: Matthias König

Submitter: Matthias König

Hünfeld 2018 presention on reproducible research and open science.

Creator: Matthias König

Submitter: Matthias König

Improved evaluation of caffeine-based dynamical liver function tests by accounting for lifestyle and pharmacological modifiers like smoking and oral contraceptive use

Matthias König1,*, Ute Hofmann2, Jan Grzegorzewski1, Reinhold Kerb2, Svitlana Igel2, Elke Schäffeler2 and Matthias Schwab2,3

1Institute for Theoretical Biology, Institute of Biology, Humboldt University, Berlin, Germany, koenigmx@hu-berlin.de, orcid.org/0000-0003-1725-179X 2Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, ...

Creator: Matthias König

Submitter: Matthias König

In the growing elderly societies, the incidence of primary and secondary liver tumors is continuously increasing. Surgical interventions like partial liver resections are often the only curative therapy removing more than 70% of the total liver mass. In humans, 20% to 30% of the remaining liver is required for liver regeneration. Successful restoration of the liver mass ultimately depends on the regenerative and metabolic capacity of the hepatocytes in the remnant liver. This, however, might be ...

Creators: Matthias König, Bruno Christ

Submitter: Matthias König

#Poster 34: LiSyM Midterm Evaluation 2018 König Group (Berlin) - Multiscale Models for Personalized Liver Function Tests

Facts & Figures

Area of Expertise: Modelling; data science; standardization Methodes: Ordinary differential equations (ODE), standardization (SBML, SED-ML); Software Development; Scientific Involvement: PillarIV Collaboration: Prof. Stockmann & Dr. Wünsch (PillarIV); Prof. Schwab & Dr. Hoffmann (PillarI); Prof. Timmer & Daniel Lill (PillarII); Prof. Holzhütter ...

Creator: Matthias König

Submitter: Matthias König

Modeling Liver Function Tests - 1st LiSyM retreat, Hünfeld, 2017-11-21

Creator: Matthias König

Submitter: Matthias König

Pillar IV Jamboree • (10 min) Introduction to Pillar IV (Hergo Holzhütter) • (20 min) Precise Measurement of Hepatic Elasticity for Fibrosis Detection (Christian Hudert) • (20 min) Tissue Scale Metabolic Modelling (Sascha Bulik) • (10 min) Multi-scale models for liver function tests (Matthias König) • (20 min) Improving the diagnostic precision of the 13C-methacetin dynamic liver function test (LiMAx) (Tilo Wünsch) • (20 min) Mathematical Modelling of Improved Liver Function Breath Test (Hergo ...

Creator: Tilo Wuensch

Submitter: Matthias König

Pillar IV Jamboree • (10 min) Introduction to Pillar IV (Hergo Holzhütter) • (20 min) Precise Measurement of Hepatic Elasticity for Fibrosis Detection (Christian Hudert) • (20 min) Tissue Scale Metabolic Modelling (Sascha Bulik) • (10 min) Multi-scale models for liver function tests (Matthias König) • (20 min) Improving the diagnostic precision of the 13C-methacetin dynamic liver function test (LiMAx) (Tilo Wünsch) • (20 min) Mathematical Modelling of Improved Liver Function Breath Test (Hergo ...

Creator: Matthias König

Submitter: Matthias König

Pillar IV Jamboree • (10 min) Introduction to Pillar IV (Hergo Holzhütter) • (20 min) Precise Measurement of Hepatic Elasticity for Fibrosis Detection (Christian Hudert) • (20 min) Tissue Scale Metabolic Modelling (Sascha Bulik) • (10 min) Multi-scale models for liver function tests (Matthias König) • (20 min) Improving the diagnostic precision of the 13C-methacetin dynamic liver function test (LiMAx) (Tilo Wünsch) • (20 min) Mathematical Modelling of Improved Liver Function Breath Test (Hergo ...

Creator: Christian Hudert

Submitter: Matthias König

Pillar IV Jamboree • (10 min) Introduction to Pillar IV (Hergo Holzhütter) • (20 min) Precise Measurement of Hepatic Elasticity for Fibrosis Detection (Christian Hudert) • (20 min) Tissue Scale Metabolic Modelling (Sascha Bulik) • (10 min) Multi-scale models for liver function tests (Matthias König) • (20 min) Improving the diagnostic precision of the 13C-methacetin dynamic liver function test (LiMAx) (Tilo Wünsch) • (20 min) Mathematical Modelling of Improved Liver Function Breath Test (Hergo ...

Creator: Sascha Bulik

Submitter: Matthias König

Pillar IV Jamboree • (10 min) Introduction to Pillar IV (Hergo Holzhütter) • (20 min) Precise Measurement of Hepatic Elasticity for Fibrosis Detection (Christian Hudert) • (20 min) Tissue Scale Metabolic Modelling (Sascha Bulik) • (10 min) Multi-scale models for liver function tests (Matthias König) • (20 min) Improving the diagnostic precision of the 13C-methacetin dynamic liver function test (LiMAx) (Tilo Wünsch) • (20 min) Mathematical Modelling of Improved Liver Function Breath Test (Hergo ...

Creator: Sascha Bulik

Submitter: Matthias König

Pillar IV Jamboree • (10 min) Introduction to Pillar IV (Hergo Holzhütter) • (20 min) Precise Measurement of Hepatic Elasticity for Fibrosis Detection (Christian Hudert) • (20 min) Tissue Scale Metabolic Modelling (Sascha Bulik) • (10 min) Multi-scale models for liver function tests (Matthias König) • (20 min) Improving the diagnostic precision of the 13C-methacetin dynamic liver function test (LiMAx) (Tilo Wünsch) • (20 min) Mathematical Modelling of Improved Liver Function Breath Test (Hergo ...

Creator: Sascha Bulik

Submitter: Matthias König

Pillar IV Jamboree • (10 min) Introduction to Pillar IV (Hergo Holzhütter) • (20 min) Precise Measurement of Hepatic Elasticity for Fibrosis Detection (Christian Hudert) • (20 min) Tissue Scale Metabolic Modelling (Sascha Bulik) • (10 min) Multi-scale models for liver function tests (Matthias König) • (20 min) Improving the diagnostic precision of the 13C-methacetin dynamic liver function test (LiMAx) (Tilo Wünsch) • (20 min) Mathematical Modelling of Improved Liver Function Breath Test (Hergo ...

Creator: Niklas Heucke

Submitter: Matthias König

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