Chronic Liver Disease Progression (LiSyM-DP - Pillar II) (Leibniz-Institut für Arbeitsforschung (IfADo)) ; Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III) (Leibniz-Institut für Arbeitsforschung (IfADo)) ; LiSyM network (Leibniz-Institut für Arbeitsforschung (IfADo))
The incidence of this life-threatening acute-on-chronic liver failure (ACLF) is increasing, and early detection and cure are urgent clinical needs. Pillar III applies a Systems Medicine approach to identify the critical mechanisms of acute-on-chronic liver failure (ACLF) and to foster liver regeneration and repair.
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Chronic liver diseases (CLD) progression leads to cirrhosis, often cancer, and ultimately to organ failure and death. Because of the complexity of this scenario, a Systems Medicine approach is chosen to develop strategies to better characterize progression and resolution of fibrosis. Pillar II aims to define key molecular mechanisms and structural changes in tissue architecture during the progression of CLD by visualizing and quantifying at a cellular level, tissue and organ scale.
Authors: Geert Peeters, Charlotte Debbaut, Wim Laleman, Adrian Friebel, Diethard Monbaliu, Ingrid Vander Elst, Jan R Detrez, Tim Vandecasteele, Tim Johann, Thomas De Schryver, Luc Van Hoorebeke, Kasper Favere, Jonas Verbeke, Dirk Drasdo, Stefan Hoehme, Patrick Segers, Pieter Cornillie, Winnok H De Vos
Date Published: 28th Dec 2016
Journal: Journal of anatomy
PubMed ID: 27995631
Citation: J Anat. 2017 Mar;230(3):471-483. doi: 10.1111/joa.12567. Epub 2016 Dec 20.
Authors: G. Peeters, C. Debbaut, A. Friebel, P. Cornillie, W. H. De Vos, K. Favere, I. Vander Elst, T. Vandecasteele, Tim Johann, L. Van Hoorebeke, D. Monbaliu, Dirk Drasdo, Stefan Hoehme, W. Laleman, P. Segers
Date Published: 4th Dec 2017
Journal: J Anat
PubMed ID: 29205328
Citation: J Anat. 2017 Dec 4. doi: 10.1111/joa.12760.
Computational models complement experimental methods in the analysis of tissue organization processes, and play an increasingly important role in systems biology and systems medicine. Creating and parameterizing mathematical models for the simulation of biological tissue dynamics at multiple scales is still a complex and resource-consuming task, which necessitates skills in diverse scientific disciplines. The software TiSim was conceived to facilitate programming, integration and deployment of
Contributor: Tim Johann