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SEEK ID: https://seek.lisym.org/people/106
Location:
Germany
Expertise: Not specified
Tools: Not specified
Chronic Liver Disease Progression (LiSyM-DP - Pillar II) (Leibniz-Institut für Arbeitsforschung (IfADo)) ; Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III) (Leibniz-Institut für Arbeitsforschung (IfADo)) ; LiSyM network (Leibniz-Institut für Arbeitsforschung (IfADo))
Related items
The incidence of this life-threatening acute-on-chronic liver failure (ACLF) is increasing, and early detection and cure are urgent clinical needs. Pillar III applies a Systems Medicine approach to identify the critical mechanisms of acute-on-chronic liver failure (ACLF) and to foster liver regeneration and repair.
Public web page: Not specified
Organisms: Not specified
Chronic liver diseases (CLD) progression leads to cirrhosis, often cancer, and ultimately to organ failure and death. Because of the complexity of this scenario, a Systems Medicine approach is chosen to develop strategies to better characterize progression and resolution of fibrosis. Pillar II aims to define key molecular mechanisms and structural changes in tissue architecture during the progression of CLD by visualizing and quantifying at a cellular level, tissue and organ scale.
Public web page: Not specified
Organisms: Mus musculus, Rattus rattus, Rattus norvegicus
This comprises the whole LiSyM network
Public web page: http://www.lisym.org
Organisms: Rattus norvegicus, Rattus rattus, Mus musculus, Homo sapiens
Abstract (Expand)
Authors: Geert Peeters, Charlotte Debbaut, Wim Laleman, Adrian Friebel, Diethard Monbaliu, Ingrid Vander Elst, Jan R Detrez, Tim Vandecasteele, Tim Johann, Thomas De Schryver, Luc Van Hoorebeke, Kasper Favere, Jonas Verbeke, Dirk Drasdo, Stefan Hoehme, Patrick Segers, Pieter Cornillie, Winnok H De Vos
Date Published: 28th Dec 2016
Journal: Journal of anatomy
PubMed ID: 27995631
Citation: J Anat. 2017 Mar;230(3):471-483. doi: 10.1111/joa.12567. Epub 2016 Dec 20.
Abstract (Expand)
Authors: G. Peeters, C. Debbaut, A. Friebel, P. Cornillie, W. H. De Vos, K. Favere, I. Vander Elst, T. Vandecasteele, Tim Johann, L. Van Hoorebeke, D. Monbaliu, Dirk Drasdo, Stefan Hoehme, W. Laleman, P. Segers
Date Published: 4th Dec 2017
Journal: J Anat
PubMed ID: 29205328
Citation: J Anat. 2017 Dec 4. doi: 10.1111/joa.12760.
Creators: Tim Johann, Dirk Drasdo, Stefan Hoehme, Paul Van Liedekerke, Johannes Neitsch
Contributor: Tim Johann
Computational models complement experimental methods in the analysis of tissue organization processes, and play an increasingly important role in systems biology and systems medicine. Creating and parameterizing mathematical models for the simulation of biological tissue dynamics at multiple scales is still a complex and resource-consuming task, which necessitates skills in diverse scientific disciplines. The software TiSim was conceived to facilitate programming, integration and deployment of
...
Creators: Tim Johann, Jieling Zhao, Stefan Hoehme, Dirk Drasdo, Andreas Buttenschön, Noémie Boissier, Géraldine Cellière, Paul Van Liedekerke, Johannes Neitsch
Contributor: Tim Johann
Creators: Tim Johann, Dirk Drasdo, Ayham Zaza, Jieling Zhao, Paul Van Liedekerke
Contributor: Tim Johann