Hepatocellular Carcinoma
Version 1

The model studies the influence of hepatocyte–sinusoid alignment (HSA), i.e. the orientation of the division plane such that daughter hepatocytes align with nearby sinusoids, on the shape of tumor nodules in liver lobules. It employs the structure of the model ‘Liver Regeneration from CCl4’ (https://seek.lisym.org/models/19).

Originally, Höhme et al. (https://doi.org/10.1007/s11538-017-0375-1) employed a center-based model. Here, the model is encoded in the standardized language MorpheusML. Using the same processes and parameter values wherever possible, the published results are reproduced quantitatively by a cellular Potts model (CPM). While the original model considered a three-dimensional liver lobule, the MorpheusML model represents the two-dimensional cross section with correspondingly lower cell numbers.

The exponential form of the growth kinetics is reproduced as well as the slightly faster growth of clones with HSA. Tumors in which cells obey HSA show significant elongation and high aspect ratio that decreases with time matching the original data.

The detailed quantitative comparison is presented under https://identifiers.org/morpheus/M9148.

SEEK ID: https://seek.lisym.org/models/20?version=1

1 item (and an image) are associated with this Model:
  • HCC-MorpheusML.xml (XML document - 33.6 KB) Download

Organism: Rattus norvegicus

Model type: Agent based modelling

Model format: MorpheusML

Execution or visualisation environment: Morpheus

Model image: (Click on the image to zoom) (Original)

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Created: 14th Jun 2024 at 13:22

Last updated: 14th Jun 2024 at 13:22

Version History

Version 1 (earliest) Created 14th Jun 2024 at 13:22 by Diego Jahn

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