LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (ACLF)
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Created: 12th Jul 2018 at 17:19
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Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, LiSyM network, LiSyM-Krebs Partnering
Institutions: HITS gGmbH
https://orcid.org/0000-0002-8683-7084
Data management and standardization expert for systems biology and systems medicine, responsible for the data management user requirements and user contacts within the German LiSyM network (Liver Systems Medicine: http://lisym.org/) and associated to the FAIRDOM team. Involved in different standardization initiatives and committees, i.e. COMBINE (http://co.mbine.org), ISO/TC 276 Biotechnology (https://www.iso.org/committee/4514241.html), European COST action CHARME (http://www.cost-charme.eu) and ...
Liver Systems Medicine : striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research. LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety. LiSyM research focuses on the metabolic liver disease non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis ...
Projects: LiSyM Core Infrastructure and Management (LiSyM-PD), LiSyM Pillar I: Early Metabolic Injury (LiSyM-EMI), LiSyM Pillar II: Chronic Liver Disease Progression (LiSyM-DP), LiSyM Pillar III: Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF), LiSyM Pillar IV: Liver Function Diagnostics (LiSyM-LiFuDi), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), LiSyM PALs, Project Management PTJ, LiSyM network, LiSyM Scientific Leadership Team (LiSyM-LT)
Web page: https://www.lisym.org/
In chronic diseases, at some point the liver can suddenly stop functioning. This is called acute-on-chronic liver failure, or ACLF. This is the leading cause of death in liver patients and is often provoked by the use of transcription or freely available drugs or alcohol abuse. For this condition we need an effective treatment quickly. LiSyM-Pillar III researches the factors that contribute significantly to ACLF. What exactly happens then? Are there any early signs that would enable ACLF to be ...
Programme: LiSyM: Liver Systems Medicine
Public web page: http://www.lisym.org/our-work/pillar-research
Start date: 1st Jan 2016
Submitter: Alain Becam
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Assays: OpenBIS FILES
Submitter: Alain Becam
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Assays: OpenBIS FILES
Submitter: Alain Becam
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Assays: OpenBIS FILES
Automatically generated assay to host openbis files that are linked to the original OpenBIS experiment. Its content and linked data files will be updated by the system if automatic synchronization was selected.
Submitter: Alain Becam
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Study: OpenBIS E522
Automatically generated assay to host openbis files that are linked to the original OpenBIS experiment. Its content and linked data files will be updated by the system if automatic synchronization was selected.
Submitter: Alain Becam
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Study: OpenBIS E521
Automatically generated assay to host openbis files that are linked to the original OpenBIS experiment. Its content and linked data files will be updated by the system if automatic synchronization was selected.
Submitter: Alain Becam
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Study: OpenBIS E520
Automatically generated assay to host openbis files that are linked to the original OpenBIS experiment. Its content and linked data files will be updated by the system if automatic synchronization was selected.
Submitter: Alain Becam
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Study: 1 hidden item
Submitter: Alain Becam
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: LiSyM Pillar III: Regeneration and Repair in Ac...
Study: 1 hidden item
Non-alcoholic fatty liver disease and nonalcoholic steatohepatitis can lead to advanced liver disease. Both conditions are becoming increasingly prevalent as the epidemics of obesity and diabetes continue to increase. A mathematical model was built to understand how the disease burden associated with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis will change over time. Results suggest increasing cases of advanced liver disease and liver-related mortality in the coming years.
Creators: None
Submitter: Ina Biermayer
