City: 04103 Leipzig
Group leader of the junior group: The Hedgehog Signalling Pathway (LiSyM-JGMMS)
Day-to-day science within the LiSyM is overseen and directed by the the LiSyM Scientific Leadership Team. This coordination team comprises the pillar coordinators and additional LiSyM members, and ensures smooth interaction between multi-skilled groups, often working in different institutions and across significant distances within Germany.
Public web page: http://www.lisym.org/governance
Organisms: Not specified
Identification of key processes leading to non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steato-hepatitis (NASH): Based on the finding within the Virtual Liver Network that the Hedgehog signalling pathway is a core player in the regulation of liver lipid metabolism, this project aims to characterize and model the central role of Hedgehog signalling during the transition from benign steatosis to NAFLD and NASH using patient data and large data sets from various